Striker vs Goal Keeper
Romelu Lukaku vs Ciprian Tatarusanu
With the suspension of Milan's number 1, it will fall to Tatarusanu to keep the Milan goal guarded. Corners, crosses, and any ball in the air will surely find their way to Lukaku, and this will be an extremely important factor if Milan are to bounce back after the latest league defeat. Tatarusanu needs to be confident and choose when to come, and when to stay.
Center Midfield vs Center Midfield
Marcelo Brozovic vs Frank Kessie
Kessie and Brozovic will both aim to break play and be essential to controlling the midfield, with each likely to be getting in each others way during any counter-attacks.
Left Forward vs Right Wing Back
Rafael Leao vs Ivan Perisic
Inter are likely to rotate and Perisic start in their preferred 3–5–2 formation. This should open up space for Leao, with Perisic more likely to go forward and neglect his defensive duties.